What is Metabolic Detoxification?
Detoxification is the metabolic process of removing unwanted lipid-soluble compounds from the body.
These “unwanted” compounds can be endogenous (e.g. excess hormone) or foreign (e.g. environmental toxicant) in nature.
Detoxification reactions occur throughout the body - the liver is the predominant detoxifying organ.
Detoxification reactions follow three phases with the ultimate goal of converting the toxin into an inert, water-soluble form for excretion:
Phase I (bioactivation) reactions will transform the toxin into a chemical form that can be metabolized by the phase II enzymes. These reactions are performed primarily by the cytochrome P450 enzymes.
Phase II (conjugation) reactions attach the toxin to other water-soluble substances to increase its solubility. Each of the different types of phase II enzymes catalyzes a different type of conjugation reaction.
Some of the main ones:
UDP-glucuronlytransferases (UGTs) catalyze the glucuronidation of most clinical drugs, and several environmental toxins
Glutathione-S-transferases (GSTs) conjugate toxins with the antioxidant glutathione; they can also directly detoxify free radicals
Sulfotransferases (SULTs) catalyze sulfonation reactions; they may also be important for controlling sex hormone levels
(Other types of phase II reactions that are used less frequently include methylation and amino acid conjugation reactions).
Phase III (Elimination) detoxification involves the transport of the transformed, conjugated toxin into or out of cells. Different phase III transport proteins work together to shuttle toxins from different parts of the body into bile or urine for excretion.
Following the detoxification reactions, the toxins are then removed from the body by excretion:
Products of liver detoxification often leave the body by being secreted into the intestines in bile, but can sometimes be transported into the bloodstream for processing by the kidneys.
The cells that line the intestines can detoxify toxins as they are absorbed, and release them back into the intestinal lumen.
The kidneys can filter and further process toxins from circulation, excreting them from the body as urine.
Via the skin as sweat
In a perfect world your body is quite adept at managing these processes without any issues. But when you’ve been living a lifestyle of poor food choices, high stress and in a society full of pollutants, it’s no wonder your system may back up.
Just like a sewerage tank that becomes too full,
if you ignore the problem, it’s not going to disappear.
You cannot simply add a few products and decrease the sewerage or remove the sewerage tank!
You need to simplify all aspects of your life, including:
The right diet - including good quality raw fruit and vegetables
The right mind - a life full of peace is just as important as the right food
Exercise - a daily regimen of quality exercise (cardio and strength training) can go a long way in helping the toxins to move out your body
Sunshine and natural spring water - getting outside to appreciate life and drinking water
Let us first bust some myths behind the word detox
Detoxes are scary and dangerous - NO. A well-planned nutritionally balanced diet, regular exercise with enough sunshine, water and stress-reducing effects can help the NATURAL processes of your body
Most detoxes involve food restrictions - NO. They shouldn’t. Fasting is a hot topic at the moment and should always be well-supervised and planned. When I speak about food restricting, I am only ever refering to processed food - non-natural food
Your body is more than capable of detoxing itself - HALF TRUE. We have been blessed with amazing organs that work in harmony to keep our bodies in a state of homeostasis. BUT, as I mentioned before, if we live in a constant state of stress , bad diet and lack of physical exercise - our body is going to bear the brunt of it
You only truly detox if you have multiple detox symptoms - YES and NO. Some people are fortunate enough not to suffer and consequences (which may include: Fatigue, headaches, stomach issues, sinus issues and many more) and others may get them all! As I said in my previous BLOG, it is important to see the big picture.
You can google DETOX and come across many sites saying that it is a waste of time, or not proven or dangerous.
But think about it. How can cutting out bad food, exercising, drinking more water and reducing the stress in your life be a bad thing? It should be a CHANGE OF LIFESTYLE…a new way of thinking even.
There is a very real link between an acid-based lifestyle and general poor health and metabolic diseases (a blog for another time). Simply put: the more acid-based your diet, the more you are going to battle with your health.
My main focus in assisting people moving towards good health, is to get them to look at the food that they are consuming as well as their day-to-day lifestyle choices.
I want to offer you a simple 10-day program that includes professional help with:
1. targeted nutrition (no calorie restriction here!) together with
a simple eating plan that will begin with 3 days of elimination,
2. an easy-to-follow cardio and strength training schedule
3. some guidance with regards to mental well-being and ways to manage and reduce stress
This offer has not yet been advertised on my website and is exclusively for my subscribers first!
Before I leave, I must share my favorite juice and smoothie recipe:
Berry Pear smoothie:
2 pears - decored
2 bananas - peeled
1 cup frozen berries
1 tsp lemon juice - freshly squeezed
4 cups baby spinach
Water as needed
Blend to desired consistency
The Green Carrot juice:
6 large carrots - peeled
1/2 a lemon
1 cup of mixed greens including some carrot tops
Juice all the ingredients and drink straight away
Have a great week and see you next week!
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